It is worth saying that it is a peculiar vertex of the network, being composed of 104 institutes spread over geographically distributed sites (in all the biggest cities in Italy), and covering a large spectrum of activities in many fields, from pure research, to applied disciplines.
KT encompasses a large spectrum of activities, from discovery of knowledge (innovation) to its implementation (adoption) in real-world settings.
The presence of SerpinB2 on MPs may also be a key to unraveling the disparate activities reported for SerpinB2 1. MPs control a large spectrum of activities in inter alia cancer, inflammation and apoptosis, with the cellular source of the MPs often determining their activities 34, 39, 46.
The extracts from A. hybridus, V. hymenolepis, L. sativa, L. carpensis and M. esculenta also exhibited large spectrum of activity as they were active on 28/29 tested bacteria.
Aminobutyric acid derivative, such as β-aminobutyric acid (BABA), an inducer of disease resistance in plants possesses a large spectrum of activity in inducing resistance against disease in peas, potato, tomato, tobacco, apple, grapevine, cucumber, and other plants [7, 8].
AMPs are among the most promising candidates, in view of their small size (which simplifies their chemical synthesis), a large spectrum of activity against gram positive and gram negative bacteria, and limited toxicity towards eukaryotic cells [4], [5].
The top eight active extracts, with large spectra of activity, showed MIC values generally ranging from 128 to 512 μg/ml.
The largest spectrum of activity was recorded with B. oleacera var.
Capsicum frutescens extract displayed the largest spectrum of activity, 73% (16/22) against the tested bacteria; followed by Brassica oleacera var.
facilulatum extract displayed the largest spectrum of activity (73%) against the tested bacterial strains whilst the lower MIC value (256 μg/mL) was recorded with Basilicum polystachyon against E. aerogenes ATCC 13048 and P. stuartii ATCC 29916.
However, the species tested in this study seem to be more active considering its inhibitory properties (Highest ID = 30 mm, MIC = 0.15, vs. ID = 18 mm, MIC = 625 μg/ml in their study) and to possess a larger spectrum of activity against tested microorganisms.
