Sentence examples for large simplification from inspiring English sources

A potential problem with this approach is that it will be dependent on the thresholds used in peak finding, and it also models average transcription factor binding in a cell population as on-off events, which is a large simplification.

Because the discussed model only addresses the overall PPI network evolution, the more detailed features of this process, i.e., the fast asymmetric functional divergence of duplicated genes [ 28] or the modular preferential attachment [ 18] were disregarded, offering a large simplification with no loss of prediction ability.

However, the full decision space of these objectives is usually very large and simplifications are necessary to safeguard computational feasibility.

Computational modelling of this setting (multiple cell populations with heterogeneous biophysical and biochemical coupling) is challenging, and still based on a large degree of simplification.

One example of this would be to consider epidemiological dynamics of sub-populations much larger than households, either ecologically-motivated or as a simplification of large-scale structured models of human and animal disease.

Since the proposed procedure for constructing reduced mechanisms is fully algorithmic and requires minor computations, it is very much suited for the simplification of large detailed mechanisms.

In order not to get lost in the large quantities of data, simplification schemes that still contain the key elements of the reaction are required.

Advantages include simplification of larger or more complex numbers and agreement of nomenclature among the scientific community.

Even with such simplifications, a large number of phenomenological kinetic parameters are introduced in the governing model equations, which must be estimated from available sparse in vivo experimental data.

Large-scale methods require simplification of procedures and the therapeutic purpose emphasizes the problem of safety.

We present algorithms for efficient symbolic simplification of such large expressions.