Sentence examples for large selective advantage from inspiring English sources

This may also partially explain our observation that variants with a large selective advantage are seen in primary infection.

That is, protective HLA class I alleles tended to present epitopes at which the variant had a weak selective advantage, whereas, susceptibility alleles tended to present epitopes at which the variant had a large selective advantage.

We suggest that epitopes at which escape variants have a large selective advantage and epitopes presented by susceptibility alleles (associated with rapid progression to AIDS) were less likely to be targeted by CTL because they had experienced more frequent escape.

Consequently, one possible explanation for the observed association between a large selective advantage and a high risk of progression to AIDS was that, by chance sampling, individuals with primary infection were more likely to bear susceptibility alleles.

In the absence of a genetic barrier, population genetics theory [34] predicts that escape variants with a large selective advantage will grow out more frequently than those with a small selective advantage (Fig. 3).

Regardless of their origin, these rare cDNA amplicons (448 bp, 52.7% GC) should have a large selective advantage over the full-length co-terminal cDNA (1087 bp, 60.1% GC) during subsequent cycles of PCR.

In an experiment where very large selective advantages are expected, more regular sampling would be beneficial for the purposes of this method (in Supplementary Tables, we have applied a heuristic cut off such that f i >0.5→0.5 in order to prevent these events biasing the reported fitness ratio statistics).

Further, they would spread more quickly in our BY lines where they provide a larger selective advantage.

However, the energy reserves in the collagen of whalebones were a large untapped energy source offering a great selective advantage to, and rapid evolution of organisms that could utilize it.

We propose that errors in transcription and translation may allow selection for the intermediate mutations, if the final trait provides a large enough selective advantage.

Given the large ~20% selective advantage of these mutations, why is rifampicin resistance not fixed throughout E. coli sensu lato?