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However, the surgical repair for peripheral nerve injury, especially for large segmental defects, is not satisfactory.
Large segmental defects of long bones comprise a complex pathology resulting from a variety of aetiologies.
They are strongly interested in evaluating their concepts in highly reproducible large segmental defects in preclinical and large animal models.
In case of large segmental defects in load-bearing bones, an external fixator is used to provide mechanical stability to the defect site.
Repairing large segmental defects in long bones caused by fracture, tumour or infection is still a challenging problem in orthopaedic surgery.
For certain types of implants that are designed to fill very large segmental defects in appendicular bones, such as those used in limb sparing, compression testing does not provide the necessary insight into the complex loading states typical of bending.
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The goal of this study is to develop and validate a 3D anatomical FE model of a bone fixator system which includes a previously developed unilateral external fixator for a large segmental defect model in the rabbit tibia.
First, the large segmental defect was exposed via an anterior approach.
In 1995, Chmell et al. [ 2] used a structural allograft for a large segmental defect >10 cm in size.
Our previous study in a large segmental defect model showed successful new bone formation when the defects were filled with highly porous and interconnected HA scaffolds [ 9].
The aim of the present study was to verify whether cultured autologous bone marrow stromal cells (BMSCs) loaded onto irradiated bone allografts would result in effective bone repair at the site of a large segmental defect in sheep tibia.
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