Sentence examples for large scale trial on from inspiring English sources

As a co-principle investigator he completed the largest trial ever performed on intrathecal pumps versus medical management, and the first large scale trial on a novel intrathecal agent for pain.

To develop the concept of nutritionally functional food it is necessary to identify the biologically active molecules, to understand the mechanisms of prevention and protection, and to demonstrate the efficacy of these molecules by means of a large scale trial on humans.

"We usually have only one shot at a very large-scale trial on a particular issue," he said.

The aim of this study was to conduct a pilot randomised controlled parallel arm trial, to establish key features required for the design and implementation of a large-scale trial on acupuncture for chronic neck pain.

Important data for future research will include feasibility of recruitment, and retention to a large scale trial, and estimates of effect sizes on key outcome variables which can inform future power calculations.

Large scale trial is required to evaluate whether there are the beneficial effects of pre-warming on the shivering.

The present study builds on this successful pilot work to conduct a large-scale trial of this approach.

If there is firm evidence that the effect of vitamin E supplementation on health outcomes of the ATBC participants is heterogeneous, this would imply that subgroup analyses in other large-scale trials on vitamin E, and possibly in large-scale trials on other subjects, should be encouraged rather than discouraged.

Because 24-h ABPM has not been routinely used in large-scale trials on antihypertensive treatment, the protective effect of treatment-induced changes in 24-h BPV with respect to the concomitant changes in mean BP levels still needs to be properly documented.

The data from this field trial provided results supporting the use of high quality sewage sludge amendment for remediation of contaminated and barren soils, and large scale trials should be followed up on various degraded soil types.

"Large-scale trials of sodium reduction on hard outcomes, such as heart attacks, strokes and deaths, in general populations are impossible, for logistical considerations, and will never be done," said Dr. Lawrence Appel, an epidemiologist at Johns Hopkins Medical Institutions, and chairman of the salt committee for the 2010 United States Department of Agriculture dietary guidelines.