Comparison of the DNA sequence of the gapR STAR locus between S. aureus strains revealed a large amount of variability in this region, including differences in both repeat number and large scale structural changes.
This again illustrates how alternative conformations of local torsions stabilized through modifications of the environment contribute to larger scale structural changes such as base flipping.
That is like instructing all high-tech companies to mimic Apple, as if what makes Apple successful is an easy-to-follow cookbook for large-scale structural change.
This article uses program management (an organizational design that has been implemented in many healthcare facilities across Canada) as an example of large-scale structural change and demonstrates the importance of applying procedural and interactional justice principles to enhance the implementation of organizational change.
This would indicate that although the large-scale structural change likely remains functionally important it alone is not sufficient to regulate substrate flow and that other mechanisms are also involved.
A group of integrins is known to perform a large-scale structural change when the protein is activated, but the activation mechanism and generality of the conformational change remain to be elucidated.
We currently cannot rule out any of these models, based on the data presented here, nor can we rule out the possibility that some large-scale structural change occurs in both proteins upon binding that would allow the quenching we report here.
In addition, PTMs would typically cause only small changes on the surface of a structured protein, whereas large-scale structural changes, such as disorder-to-order transition, can be expected in a disordered region.
ATP hydrolysis in AAA2 is crucial for driving large-scale structural changes in the hexameric rings, and ATP hydrolysis in AAA1 possibly contributes to increasing the coupling efficiency of these chemical and structural events.
The producers responded to these societal changes by making large-scale structural changes to the show.
The producers responded by making large-scale structural changes to the show.
