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A number of new software applications have been developed for browsing, visualizing and interpreting large-scale sequencing datasets.
With the current award, CASA joins the NHGRI Large-Scale SequenCentersd Analysis Centers program, an NIH-supported consortium that provides large-scale sequence datasets and analysis to the biomedical community.
Large-scale sequence datasets now exist, allowing comparisons to be made for thousands of genes in all domains of life.
Large-scale sequence datasets generated primarily through Sanger Expressed Sequence Tag projects are available from a limited number of potato cultivars and access to next generation sequencing technologies permits rapid generation of sequence data for additional cultivars.
Another potential use of large scale transcript sequencing datasets is in high throughput, genome-wide SNP discovery.
Large scale EST sequence datasets have previously been reported for Triphysaria versicolor [ 8] and Triphysaria pusilla [ 27], which are hemiparasitic plants belonging to the Orobanchaceae.
We believe future large-scale sequencing efforts on tea genome and transcriptome will increase the coverage of our dataset even further.
Large-scale sequencing technologies, such as Illumina Solexa, enable evaluation of transcriptome dynamics under various conditions without sophisticated normalization of datasets [ 41].
M.C., J.J.R. and J.J. performed the large-scale sequencing.
Breakthrough in the large-scale sequencing technique has led to a surge in biological sequence information.
This implies that large-scale sequencing and large-scale computing have become inseparable.
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