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The evaluation of the NHS Newborn Hearing Screening Programme will serve as a valuable tool and example to justify and improve large scale screening programmes.
Implementation of an effective large-scale screening programme for congenital CMV infection is feasible.
Insight into the feasibility, effectiveness, cost-effectiveness, and impact of this large-scale screening programme will determine whether the programme will be implemented nationally.
Keystones for an effective large-scale screening programme are achieving adequate levels of participation [ 8] and capturing substantial numbers of new (chlamydia positive) participants in addition to regular care like STI clinics and general practitioners (GPs).
11 15 In this study, we established a multicentre congenital CMV screening programme and tested specimens from 21 272 newborns to evaluate the feasibility of our assay for a relatively large-scale screening programme, to learn the prevalence of congenital CMV infection and diseases, and to identify risk factors for congenital CMV infection in Japan.
Many large-scale screening programmes of the past failed to produce worthwhile plant-derived antimicrobial pharmaceutical products [ 5, 26].
In addition, measuring progressive motor neuron loss in mutagenized animals is not a suitable protocol for large-scale screening programmes.
Furthermore, the simplicity of the procedure avoids 'medicalization' of asymptomatic individuals, which could encourage population compliance to large-scale screening programmes.
When data from large-scale screening programmes became available, a working group of the International Agency on Research for Cancer (IARC) estimated the incidence after a negative screen, compared to the estimated background incidence in eight countries, that is, Canada, Scotland, Iceland, Denmark, Norway, Sweden, Switzerland and Italy (IARC Working Group, 1986a, 1986b).
In 1999, the development of rapid tests enabled the implementation of large-scale screening programmes which were first restricted to at-risk animals in 2000 and then extended, from January 2001, to all cattle over 30 months of age entering the food chain.
Biobanks are providing patient benefit by allowing large scale screening and generating large database repositories.
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