The future study would perform clinical trials on a larger scale sample size, and as a comparison study among conventional and 3D printed casts to assess whether clinical differences were statistically significant.
Identifying loci conferring susceptibility to osteoarthritis will require large-scale sample sizes and well-defined phenotypes to minimise heterogeneity.
Large-scale sample sizes and well-defined phenotypes will be required to gain a better understanding of this genetic component, possibly leading to optimising treatment, developing efficacious disease-modifying interventions, improving prognosis and tailoring intervention to the individual.
Additionally, sensitivity analyses according to various exclusion criteria (full-text article, large-scale trials (sample size >100), patients with pre-existing renal impairment or chronic kidney disease, elective or urgent surgery, and only elective surgery) were also conducted.
The major concern is that the majority of studies initially screen small sample sizes without validation by large-scale samples.
Therefore, the CTM-3 can be used as a substitute for the CTM-15 when administration burden is a concern or in large-scale studies where large sample sizes can compensate its suboptimal reliability.
17 Condom use in extramarital relationships is understudied mainly because large-scale surveys with large sample sizes are needed to obtain adequate data for meaningful analysis, and few such studies are available in Africa.
One has been towards larger and larger sample sizes.
Varni and colleagues [ 59] reported that across a large sample size, this scale exceeded the minimum internal reliability criterion of 0.70, and had satisfactory validity because the Peds-QL was able to distinguish between children with chronic conditions and healthy children.
This could suggest that the effect sizes on these scales are larger and requires a larger sample size to detect a statistically significant difference.
