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Large scale reviews of the antibacterial research at the pharmaceutical companies GSK [3], and, more recently, Astra Zeneca [4], have highlighted the challenges involved.
Treatments from large scale reviews that report positive effects most strongly include: allergen immunotherapy (57 trials) [ 76], beclomethasone (60 trials) [ 82], budesonide (43 trials) [ 84], fluticasone (75 trials) [ 96], ICS compared with sodium cromoglycate (25 trials) [ 88], LABA (67 trials) [ 62], and LABA vs. SABA (31 trials) [ 75].
The United Kingdom (UK) Chief Medical Officers recently published a report on physical activity (PA) for health, which has drawn upon recent international large scale reviews of the evidence of the impact of physical activity on health and included a specific chapter on older adults [ 1].
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NHS England's large scale review of all emergency services, partly driven by the premature mortality rates across hospitals, seems to have made a significant omission by overlooking mental health emergency care.
The most recent large scale review of PHES faculties was undertaken by the American Society of Civil Engineers Hydro Power Task Committee on Pumped Storage in 1996.
The capstone of this research case against talc came in 2003 when the journal Anticancer Research published a 'meta-analysis,' or large scale review, of 16 previous published studies involving 11,933 women; a 33percentt increased risk of ovarian cancer was confirmed.
In the US a large scale review exercise was undertaken of 500 life saving interventions across the areas of health, transport and environment[ 14].
A large scale review, involving 100 trials, concluded that computer-based decision support systems can improve practitioner performance but that the effects of such interventions remain both understudied and inconsistent [ 13, 15].
First, large-scale reviews of hundreds of Phase I trials have indicated there is a relatively low risk of serious harm and some prospect of clinical benefit that can be meaningful to patients.
There have been two large-scale reviews comparing administrative to self-report data [ 6, 7].
Two large-scale reviews attempted to assess the effects on LTLS/CTLS and AKI/need for RRT; these were a Cochrane database systematic review of the pediatric literature in 2014 17 and a systematic review by Lopez-Olivo et al of the adult literature in 2013.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com