Barski et al[32] generated a large scale high-resolution profiling of 20 histone methylations in human resting CD4+ T cells.
Large scale and coarse resolution biomass or carbon mapping using satellite imagery for tropical forests in Africa has been demonstrated [10, 18 20].
In the study, Lieberman-Aiden et al. modeled the Hi-C data as a probability matrix at a large scale (1 Mb resolution) and revealed the folding principles of genome organization with a sub-domain of chromatin to form genome-wide compartments.
Although the efficacy of cytological screening for cervical cancer is beyond doubt (mortality and incidence have been falling dramatically in Western Europe since screening has been adopted on a large scale), the optimal resolution of several aspects of cervical screening (e.g. compliance, criteria for referral, cost-effectiveness) is still awaited.
Plotting MeDIP-seq signal and MRE-seq signal at a large scale (500 kb resolution) revealed loss of DNA methylation across the whole X chromosome in UPSC, as evidenced by reduced MeDIP-seq signal (~20%) and increased MRE-seq signal (~60%).
Large scale and high-resolution surface pressure and Particle Image Velocimetry measurements were carried out in a new testing chamber, the WindEEE Dome, to investigate the structure of stationary tornado-like vortices and their surface layer over a broad range of swirl ratios and at the highest radial Reynolds numbers ever achieved in laboratory simulations of tornadoes.
The accelerated performance of the proposed 3-D model reaches 30 times of that of a single thread program, and the GPU-FVCOM implemented on a Tesla k20 device is faster than on a workstation with 20 CPU cores, which shows that the GPU-FVCOM is efficient for solving large scale sea area and high resolution engineering problems.
This results in high time resolution and low frequency resolution at small scale and high frequency resolution and low time resolution at large scale.
The cost of large scale use of high resolution imagery data becomes prohibitive.
As countries of Eastern Europe look to advance their agricultural markets through large scale agronomic production, high resolution mapping of soil resources will be essential.
Therefore, algorithms that can infer individual-specific recombination rates both on a large scale and with high resolution would be very useful for genomic studies of recombination hotspots.
