In addition to changes in gene expression, there is also a large-scale reprogramming of metabolism under the low oxygen conditions.
The present results show that transcript and metabolite profiles were significantly altered already in response to a moderate decrease in oxygen concentration, indicating large-scale reprogramming of gene expression and metabolism under these conditions.
In conclusion, the results of this study show that there is an adaptive decrease in root extension involving large-scale reprogramming of gene expression and metabolism in response to a mild decrease in oxygen concentration.
The results show that there are adaptive changes in root extension involving large-scale reprogramming of gene expression and metabolism when oxygen concentration is decreased in a very narrow range.
When cells change functions or activities (such as during differentiation, response to extracellular stimuli, or migration), gene expression undergoes large-scale reprogramming, in cell type- and function-specific manners.
Recent genomic studies using high resolution RNA-seq technology have established that bacteria undergo large scale global reprogramming of gene expression to cope with environmental stresses.
This larger set may point toward a set of promoters than can be epigenetically reprogrammed in the cancer process and, via overall analysis, may give insight into underlying mechanisms or molecular components of this large-scale reprogramming.
Large scale transcriptional reprogramming during the progression of PKD is consistent with a complex, multi-layered regulatory process, one of the possible regulators of which are miRNAs.
The sudden imposition of linoleic acid during exponential growth at OD600 = 3 (linoleic acid challenge) resulted in large-scale transcriptional reprogramming of genes in four major discernible categories, including: virulence, energy metabolism, stress resistance and cell wall synthesis.
On the other hand, a large scale of chromatin domains spanned by H3K9me3 that inhibit OSKM binding are known to hinder efficient reprogramming.
Are the large scale IT systems of the past redundant?
