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This raises the question on how the genome and associated transcriptome copes with such large scale reorganisations of the genome when genera and species evolutionary diverge over time.
The processes underlying the large-scale reorganisation of chromatin in mitosis that form compact mitotic chromosomes and ensure the fidelity of chromosome segregation during cell division still remain obscure.
Enhancer and super-enhancer binding by these EBNAs results in large-scale reorganisation of three-dimensional enhancer promoter architecture to drive the overexpression of oncogenes, the silencing of tumour suppressors and the modulation of transcription, cell-cycle progression, migration and adhesion.
This includes upregulation of UPR markers in the wild-type strain, which has been previously observed as a result of the switch to methanol, which requires large-scale cellular reorganisation to produce the required peroxisomes (Vanz et al. 2012; Edwards-Jones et al. 2015).
"Alyse Rosner: Large Scale Work".
He does this on a large scale.
This happens on a very large scale".
Another factor is large scale production.
On a large, large scale it would be more difficult.
Large Scale Biology Corporation.
See also: Large scale Internet telephony.
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