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22 The cost effectiveness analysis has been developed using individual patient data from a pivotal, large scale randomised controlled trial SHIfT.
A large scale randomised controlled trial is required to confirm the positive results of this acceptability and short-term effectiveness study.
The authors are currently planning a large scale randomised controlled trial to evaluate the safety and effectiveness of tranexamic acid in the treatment of postpartum haemorrhage.
This is the first large scale randomised controlled trial to test the implementation of cancer risk tools based on the Hamilton CAPER studies.
The only way of measuring these benefits prospectively in a robust manner would be through a large scale randomised controlled trial.
The plans set out in the white paper led to the design and conduct of a large scale randomised controlled trial of telehealth and telecare technologies across the south of England: the Whole System Demonstrator (WSD) evaluation project.
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A larger scale randomised controlled trial is required to confirm these findings and to determine longer term effectiveness.
Preliminary data suggested that tibolone may be safely used following breast cancer (Antoine et al 2007), but this has not been confirmed in larger scale randomised controlled trials.
This is a pilot study to investigate the feasibility of a larger scale randomised controlled trial and is a 2 × 2 factorial design with 46 participants in each cell.
The Corticosteroid Randomisation After Significant Head Injury (CRASH) trial is a large-scale, randomised, controlled trial, among adults with head injury and impaired consciousness, of the effects of a short-term infusion of corticosteroids on death and on neurological disability.
It is sobering to be reminded that the use of inodilators in the treatment of acute cardiac failure has never undergone a large-scale, randomised, controlled trial.
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