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In the case of RNA splicing, use of reporter genes can be unusually problematic as splicing is influenced or regulated by large-scale processes like chromatin modification [1], [2], [3], [4], [5], transcription [6], [7],, and mRNA export [13], [14].
But how can a purely local mechanism of action drive a large-scale process like the disassembly of a clathrin coat?
The structure of the Hsc70 auxilin coat complex and the qualitative features of the uncoating mechanism it suggests answer the question we posed at the outset: how can the local, ATP-driven clamping-unclamping cycle of Hsc70 drive a large-scale process like coat disassembly?
What might attention to these microstructures reveal about larger scale processes?
Combined analysis of the gravity anomalies and model results also explains erosion as one of the main mechanisms responsible for gravity signal for tectonically inactive regions and illustrates the interaction of short wavelength erosional processes and large scale, regional processes like active orogenesis and dynamic topography.
The company has successfully implemented intelligent agents in IT support processes, but as yet is not ready to support large-scale enterprise processes, like order-to-cash.
Large scale social process innovation, not product innovation, usually produces entrepreneurial success.
This paper deals with the optimal operation of large scale systems composed by local processes liked by shared resources.
A decision-making theory-driven, large scale assessment of this process has not been previously undertaken.
They are large scale, like projections on the wall.
The government was also trying to promote legal cultivation, but factors like high economic risk and inadequate technology for cultivation of such plants on a large scale were hampering the process.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com