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Kate Mills, a PhD student at UCL investigating developmental trajectories through childhood and adulthood, points out, "large scale population studies haven't really found evidence that we're using things like internet-related technologies to excess".
Although this was a non-blinded study by one rater in a small city in Japan, the demographic and clinical features of migraine, including prevalence of acute allodynia, were consistent with those of large scale population studies performed in several countries.
Such assessments might not be feasible in large scale population studies.
Large scale population studies, using primary care databases, for example, can be valuable complements to well designed RCT evidence.
Large scale population studies will require a large amount of samples thus it may be necessary to transfer biological samples across borders [ 22].
Early puberty onset has been related to future chronic disease; however breast bud assessment in large scale population studies is difficult because it requires trained personnel.
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Yet, no proportion was obtained from a large scale, population study, and no investigation directly estimated the larger, societal consequences of MH stigma (e.g., lost productivity).
Other clinical studies have suggested a similar association, but ours is the first large scale population study to test the hypothesis [ 17- 22].
The study is a large scale population study, similar to that of Rockwood et al. [ 12], who questioned the test-retest reliability of TUG.
It is rare that, in a large scale population study, such as a birth cohort, or even in a well run clinical investigation, the enrollment of study subjects can be done instantaneously or during a very short time interval.
These enhancers are often located where large-scale population studies of genetic variation so-called genome-wide association studies—pinpoint an increased risk of disease.
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