Sentence examples for large scale mutagenesis from inspiring English sources

This mutation was originally isolated in a large scale mutagenesis screen for recessive embryonic lethal genes [11].

Herold et al. suggested that unwords may not have a functional meaning but might be useful for large scale mutagenesis experiments [3].

Large scale mutagenesis projects are producing libraries of mutant C57BL/6 (B6) ES cells to enable the functional annotation of every gene of the mouse genome.

We have begun to develop inbred lines to facilitate genome mapping and large scale mutagenesis experiments.

Robertson's Mutator (Mu) system has been used in large scale mutagenesis in maize, exploiting its high mutation frequency, controllability, preferential insertion in genes, and independence of donor location.

Uren, A. G. et al. Large-scale mutagenesis in p19 ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

In the late 1970s, Eric Wieschaus and Christiane Nüsslein-Volhard carried out large-scale mutagenesis screens to identify genes controlling embryonic development in Drosophila.

However, large-scale mutagenesis requires hundreds to thousands of unique oligos, which are costly to synthesize and impossible to scale-up by traditional phosphoramidite column-based approaches.

Recent large-scale mutagenesis screens have made the zebrafish the first vertebrate organism to allow a forward genetic approach to the discovery of developmental control genes.

The results provide a guide for protein engineering and large-scale mutagenesis enabled by the phage display of MPs.

We demonstrated the feasibility of large-scale mutagenesis by inserting T7 promoters upstream of 2585 operons in E. coli using this method, which we call Microarray-Oligonucleotide (MO -MAGE.