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These large scale morphological changes are accompanied by mineralogical and crystallographic changes (Fig. 1I L ).
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Thus, the evolution of extraembryonic development has involved large-scale morphological changes.
Answering this question demanded solving the technical challenges of 3D measurements and the large-scale morphological changes accompanying cellular differentiation.
As the nuclei undergo large-scale morphological changes during differentiation (Fig. 1a, Additional file 1: Figure S2), it is mandatory to consider those changes and their effect on any gene heterochromatin distances [ 33].
This has several implications, namely that large-scale morphological change could occur quickly, and that similar rearrangements could occur by chance in different contexts.
The producers responded to these societal changes by making large-scale structural changes to the show.
We describe the large-scale morphological units and associated weathering products in the Tandilia and Ventania ranges.
The most recent large-scale morphological phylogeny was constructed in 1999 [ 34].
In the fossil record, the Ammonoidea (Cephalopoda, Mollusca) are well-known to display large-scale morphological macroevolutionary trends [ 27- 39].
At such a large scale even small changes matter.
It's more associated, therefore, with large scale changes.
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