Finding diagnostic specificity in large-scale molecular changes is as challenging as with non-specific morphological features like interstitial inflammation or tubular atrophy, which as well overlap between disease entities.
Mitochondrial DNA (mtDNA) presents several advantages that make it well suited for large scale molecular tagging.
Large scale molecular genetic studies ensued [summarized in: 14].
This is also supported by some larger scale molecular and combined evidence analyses [ 13, 15, 26].
Sosso, G. et al. Fast crystallization of the phase change compound GeTe by large-scale molecular dynamics simulations.
The identification of genes regulated downstream of tra and dsx provides some of the first, large-scale, molecular insights into how the sex hierarchy instructs the changes that culminate in the production of sexually dimorphic adult male and females.
Kanehisa, M., Goto, S., Sato, Y., Furumichi, M. & Tanabe, M. KEGG for integration and interpretation of large-scale molecular data sets.
Miller SJ, Rangwala F, Williams J, Ackerman P, Kong S, Jegga AG, et al. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
However, the computational expense is considerably high for large-scale molecular dynamics simulations.
This makes it a suitable candidate for large-scale molecular studies aiming at deciphering diapause characteristics.
This molecular stratification of patients, enabled by large-scale molecular characterization, is a significant step towards personalized therapy.
