Sentence examples similar to large scale loss of function from inspiring English sources

More generally, this study also highlights the interest of large scale loss-of-function screens for characterizing the molecular mechanism of action of environmental contaminants.

In our pursuit to uncover novel synthetic lethality targets of the MYC signaling pathway, we conducted a large scale loss-of-function RNAi screen in L-MYC-overexpressing lung fibroblasts and their isogenic controls.

Genome-editing technologies have recently emerged as powerful tools for large-scale loss-of-function studies in zebrafish and will provide new ways to assess tumor suppressor function in zebrafish cancer.

We have carried out a large-scale loss-of-function screen to identify genes that are required by KRAS-transformed colon cancer cells, but not by derivatives lacking this oncogene.

Database URL: http://hts.cancerresearchuk.org/db/public RNA interference (RNAi) is a natural mechanism for gene silencing that is now widely used in large-scale loss-of-function screening campaigns in the form of small-interfering RNA (siRNA) libraries that can be used to knock down genes in a high-throughput manner.

Multiple RNAi platforms are now available for performing large-scale loss of function screens on mammalian cells.

Few professions can sustain this imbalance and the large scale loss of talent.

Large scale loss of aquatic species has been witnessed due to uranium contamination.

Large scale loss of topsoil, partially retained under the trees, has led to distinctive elevated soil surface patterns.

Required for alkylation- and oxidation-induced programmed necrosis, human ALKBH7 triggers the collapse of the mitochondrial membrane and initiates large-scale loss of mitochondrial function that leads to energy depletion and cellular demise.

Mr. Annan said that large scale Israeli military operations using tanks, ground troops and attack aircraft were causing large-scale loss of life in refugee camps.