Despite promising results of fetal movement monitoring studies, none have identified a sufficiently robust method of screening for normal fetal activity to warrant large-scale introduction to antenatal care [ 4].
Small-scale clinical studies are of value before large-scale introduction to help avoid unnecessary revisions due to material failure as with the Boneloc disaster, where preclinical tests did not predict clinical failure (Nimb et al. 1993, Stürup et al. 1994, Kindt-Larsen et al. 1995).
Currently, NIPD testing to target anti-D prophylaxis is unlikely to be sufficiently cost-effective to warrant its large scale introduction in England and Wales.
The Romans employed great quantities of both low tin and high tin bronzes, especially prior to the large scale introduction of brass during the late 1st century BCE [14].
The study revealed a decrease in the area under forest and culturable blank categories and a simultaneous increase in the area under cultivation primarily due to the large scale introduction of horticultural cash crops in the state.
In this study we utilize a regional economic forest sector model, focusing on northern Sweden, in order to estimate the effect of a large scale introduction of stump harvest on the future use of forest fuel.
The "gold-standard" for answering these questions, and for assessing the long term effects of large scale introduction of MC, would be a community randomized trial, i.e. to randomize entire communities instead of individuals.
The planned large scale introduction of wood combustion based domestic heating systems in Austria (planned for up to 400,000 households) would increase the Austrian PM2.5 emission by around 6% based on an average emission of 30 mg MJ−1, if the old "high emitting" solid fuel based heating systems are not replaced.
Large scale introduction of inorganic membranes has been hindered by lack of structural definition, reproducibility, and accurate design parameters.
However, large scale introduction of engineered nanomaterials such as nZVI into the environment has recently attracted serious concerns.
In our opinion, new covered stents and refinements of existing covered stents are needed before large scale introduction of cSEMS for this indication can be recommended.
