At the same time, the rapid development of high-throughput RNA sequencing methods now provides a way to observe splicing events directly and on a very large scale, increasing the amount of data available on this phenomenon by many orders of magnitude [1].
"Because of their small size, engineered nanomaterials have unique properties that do not exist at the larger scale: increased surface area, charge, reactivity and other physicochemical properties, all of which may affect how nanomaterials interact with biological entities, like cells," says Sara Brenner, assistant professor of nanobioscience at SUNY Polytechnic Institute.
Indeed, on a larger scale, increased homozygosity owing to founder effects in dispersal from Africa appears to account for a higher incidence of deleterious alleles in Europeans than Africans (Lohmueller et al. 2008).
We note that many rock engineering projects are on the limit of precedent practice, involving large scales, increasing costs, enhanced environmental awareness and the need to understand and predict the consequences of coupled mechanisms involving stress, water, heat and chemical reactions.
"One of the major, if not the major impediments to large scale increases of human insect consumption, is the strong rejection of insects as food by most of the world's population," writes Paul Rozin in a forthcoming paper, Determinants of Willingness to Eat Insects in the USA and India, to be published in the nascent Journal of Insects as Food and Feed.
Social interactions displayed a discrete and large scale increase in intolerance as anti-Muslim hate crimes rose to historical highs and never fully returned to pre-9/11 levels.
Consistent with the clinical EEG observations, there were large scale increases in oscillatory activity, dominated by the beta band.
Adapting the procedure to a graphite felt electrode with the view of scaling up porous electrodes for large scale synthesis increased the concentration to 0.9 nmol/cm2.
Thus, the need to perform microRNA identification at such large scale has increased the demand for parallel computing.
The authors showed that the depletion of PTBP1 affects alternative splicing and triggers transcriptome changes on a large scale, which increased the propensity of the neuronal CAD cells to undergo neuron-like differentiation.
