The possibility that the ICCA syndrome is related to the existence of large-scale genomic alterations was addressed in the present study.
Tab b – Details of large-scale genomic alterations detected by CGH in the 10 GCTs.
Tab c – Details of large-scale genomic alterations detected in ovarian GCTs by five different studies.
Future studies incorporating analysis of large-scale genomic alterations such as rearrangements, chromothripsis, large deletions or insertions, will be important.
Tumours that are MSS commonly exhibit another type of instability, CIN, with abundant large-scale genomic alterations that often lead to a higher average DNA copy number.
This observation demonstrates that a subset of non-luminal breast tumours do not develop towards large-scale genomic alterations supporting the hypothesis that these tumours represent biologically important disease entities [ 20].
To better measure the impact of large-scale genomic alterations on gene expression we divided the expression values for genes located within aneuploid regions by their mean expression in the tumors without the analyzed alteration.
The combination of laser micro-dissection followed by WGA has recently emerged as a powerful tool for large scale genomic analyses of pure populations of cells, and it was used to characterize genetic alterations in pathologic conditions such as chronic pancreatitis [ 35], motor neuron disease [ 36], and various pre-malignant [ 37], and malignant tumors [ 37- 40].
Their multi-tiered approach to genomic medicine utilizes large scale genomic sequencing and analysis, paired with functional biology to advance the diagnosis, characterization, and treatment of genetic diseases.
To address this question he has developed a number of computational methods and applied them to large scale genomic data, such as genomic comparisons of humans and chimpanzees.
This indicates that the Pfam IncA domain is too specific for a large scale genomic analysis.
