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To our knowledge, this is the first report of generation of transgenic or knock-in mice obtained from lipofected mES cells and this method may facilitate large scale genomic studies of ES developmental biology or large scale generation of mouse models of human disease.
Day Zero Diagnostics hopes to change the way physicians triage patients with severe infections and make the large scale generation of genomic data by hospital microbiology labs routine that can then be used to change clinical decision making.
Recent advances in next-generation sequencing technologies allow us the large scale generation of ESTs efficiently and cost-effectively [ 39, 40].
The pUT18 vector was preferred to pKNT25, because it is a high copy number plasmid, which is helpful for large scale generation of recombinants and efficient plasmid recovery during the screening process.
Next-generation sequencing technologies have facilitated large scale generation of ESTs cost-effectively, and allowed the whole transcriptome analysis of a number of smaller scale legume crops such as chickpea, lentil, mungbean and pigeonpea [ 27- 30].
The current investigation is focused on studying gene expression, by large scale generation of ESTs, from one susceptible (TDa 95-0310) and two resistant yam genotypes (TDa 87-01091, TDa 95-0328) challenged with the fungus.
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However, there are certain requirements for the generation of HLCs: (a) an unlimited source of initial cell material is needed to ensure routine large-scale generation of the required cells; (b) the generated cultures should be reproducible in terms of their hepatic-like functionality; and (c) the established system should allow for highly efficient selection of hepatocytes.
Jo, W. et al. Large-scale generation of cell-derived nanovesicles.
High concentration photovoltaic technology promises the large-scale generation of clean-renewable energy with competitive costs.
Tidal range power plants represent an attractive approach for the large-scale generation of electricity from the marine environment.
Lorenz Studer, stem cell biologist pioneering a new method for large-scale generation of dopaminergic neurons that could provide one of the first treatments for Parkinson's disease and prove the broader feasibility of stem cell based therapies for other neurological disorders.
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