Overall, we conclude that, although TCR conformational changes do broaden TCR reactivity, with few exceptions, the underlying motions do not reflect the large-scale flexibility which is characteristic of disordered regions; rather, the motions tend to be rigid-body shifts facilitated mostly by hinge-bending movements.
In addition, packed bed systems have numerous advantages when compared to traditional cell culture systems like reduction of footprint for equivalent production capacity, decrease of operational costs by providing large scale platform, flexibility to increase production capacity, automation and integration into a fully closed manufacturing process.
The quest for large scale integrability and flexibility has very recently stimulated an increasing interest in designing quantum computing devices.
It is suited for large scale machining with more flexibility.
Topic maps on scientific writing and OA were identified as an appropriate training tool for such a large scale project requiring great flexibility.
Here, we analysed in a large scale approach whether this flexibility in evolution is only limited to a distinct number of complexes or represents a more general trend.
Dye-sensitized solar cell (DSSC) is the most promising of third generation solar cells for large scale applications due its low cost, flexibility, and scalable manufacturability.
Middleware solutions for Heterogeneous Distributes System aim to respond to high requirements of large scale distributed applications related to performance, flexibility, extensibility, portability, availability, reliability, safety, security, trust, and scalability, in the context of high number of users, and large geographic distribution of heterogeneous hardware and software resources.
Although some docking methods accounting for protein flexibility exist, most large scale virtual screening approaches work with rigid protein models.
Comparison with other carrier protein-dependent multienzymes highlights a characteristic range of large-scale interdomain flexibility in this important class of biosynthetic enzymes.
The tradeoff between realistic and accurate descriptions of large-scale dynamics, flexibility, computational feasibility, ease of use, and accessibility of these tools creates a major challenge from both the theoretical and the computational points of view [ 4, 5, 11, 10, 13].
