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The simulator was then calibrated with several real-world large-scale experimental datasets.
In this study, we sought to systematically validate whether FBA can be used to determine gene essentiality in cancer cell metabolism by comparing predictions with large-scale experimental datasets (Fig. 1).
These problems make it essentially impossible to compare computational methods or large-scale experimental datasets and also result in conclusions that generalize poorly in most biological applications.
This manuscript addresses the distribution of CPEs in the human bidirectional promoters using computational analyses of current large-scale experimental datasets as well as motif analyses.
To show that the performance improvements we have seen on simulated data translate to large-scale experimental datasets, we applied MITIE to a dataset of seven developmental stages of D. melanogaster (550 M alignments from 38 RNA-Seq libraries for seven developmental stages).
A large network of practitioners could facilitate large scale, experimental based projects for example.
Hitherto predicted M. tuberculosis H37Rv PPIs in the STRING database (version 8.3 contains 248,574 PPIs covering 3,965 proteins in H37Rv) [ 3] have seen the most frequent used [ 4- 6] because large-scale experimental PPI datasets have not been available until recently.
These results show the power of combining different data sources and how easily the new predictor can be used to extract valuable functional protein interactions from large-scale experimental protein interaction datasets.
Integration of large-scale independent experimental datasets in public domain revealed that certain well studied lncRNAs harbor small RNA clusters.
One of the main challenges of modern bioinformatics is to develop methods and techniques that can help inferring knowledge from accumulated datasets and large-scale experimental data.
Moreover, a unique p-value is produced for each channel-sample pair such that specific questions can still be asked of the dataset while providing general information regarding the large-scale experimental effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com