In conclusion, their reproducible production and standardized quality renders HaCaT organotypic cocultures an excellent tool for large scale examinations of mechanisms regulating skin reepithelialization and homoeostasis in a tissue-type context.
While previous studies have examined smaller plant genomes (Ibarra-Laclette et al. 2013), the large-scale examination of genome reduction potential may provide a foundation for understanding the minimal soybean genome.
I remembered this incident when I read a study published this week in Archives of Surgery, the first large-scale examination of attitudes toward pregnant surgeons.
But whereas The Three was a freewheeling narrative set globally, Day Four is a more introspective, claustrophobic story set aboard a cruise liner in the Gulf of Mexico; and where the previous novel was a large-scale examination of worldwide disaster and cultural mores, Day Four plays with our dread of confinement and impending death.
As Freitas told VICE, it's a "large-scale examination of consent education".
CAMS also provided a large-scale examination of the relative and combined efficacy and safety of the best evidenced-based psychosocial (CBT) and pharmacologic (SSRI) treatments to date for the most commonly occurring pediatric anxiety disorders.
Our study greatly extends this earlier work, adding large-scale examination of databases of known transcription factor binding sites and the powerful tool of comparative genomics, as well as using a larger dataset of more than 300 OR promoter sequences.
However, there have been no large-scale examinations of these relationships among demographically diverse populations.
While many large-scale examinations of the genetic architecture of inbred mice have been completed [6], [7], [8], [9], [10], [11], no comparable evaluations of commercially available outbred strains, including CD-1 mice, have been reported.
However, more preferable tools for large scale examinations - either the molecular analysis of regulatory processes or pharmaco-toxicological studies - are skin equivalents composed of cell lines, which are easier to handle and to standardize.
The ethical issues raised by the collection of biomarkers in large-scale examination surveys, and standards for implementation have been developed over the past four decades in national population-based surveys done in developed countries [ 12].
