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While significant advances have been made in technical aspects of the AFLP methodology, theoretical studies investigating methods for optimizing the cDNA-AFLP screens remain relatively rare, and large scale empirical data - as provided here for eukaryotes - have not yet been used for this purpose [ 6- 8].
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There has been only one large scale empirical study of early childhood development in Hong Kong using a large and representative sample (Opper 1996) and the data were collected over 20 years ago.
This paper presents the results of a large scale empirical study of coherent dependence clusters.
Large scale empirical studies are lacking in this area.
Many large scale empirical studies have adopted a quantitative approach to investigating the phenomenon.
We designed a SNP ascertainment and genotyping strategy that closely matched what was used by the ENCODE Project, allowing us to use ∼2.5 Mb of the ENCODE data that had also been genotyped at the Broad Institute as a large-scale empirical control data set (Supplementary Material, Fig. S1).
In a large-scale empirical study, Pickering and Davis [ 21] used Demographic Health Survey data from 26 countries to model the effect of water collection time on child health.
Even experts do not know, because there has never been a large-scale, empirical study.
Large-scale empirical research on antecedents of the entrepreneurial effectiveness of universities is scarce.
They find that there are large-scale empirical studies that primarily focus on comparisons between male and female entrepreneurs.
Despite its importance, especially for the advancement of basic and early-stage science, there is currently no large-scale empirical evidence on how successfully governments select research investments.
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