Because the conformational transition of the hexyl tail does not involve bond-breaking or -forming, the MM approach can be used to investigate the large scale effect of the hexyl tail on the enzyme.
Ultimately, our results could have larger scale effects on eco-evolutionary community dynamics.
Given the brain network dynamics, we hypothesized that SSRs have additional large-scale effects on the brain functional network that can be revealed by means of graph theory.
However, genomic analyses of communication signal senders has not kept apace with analyses of receivers, and it is not known whether sending a communication signal is associated with comparably large-scale effects on brain gene expression.
miRNAs are regulatory, non-coding RNAs about 21 23 nucleotides in length and are expressed at specific stages of tissue development or cell differentiation, and have large-scale effects on the expression of a variety of genes at the post-transcriptional level.
We next investigated patterns of large-scale effects on the regulatory architecture that are attributable to founder and/or subspecies of origin.
NAP1L5 has sequence similarity to NAP1, a cytoplasmic-nuclear shuttle protein for histones, that has large-scale effects on gene expression by chromatin restructuring [ 113].
Previous work has shown that bacteria possess diverse adenine methylation systems with a wide range of specificities and activities (Low et al. 2001; Murray et al. 2012), and that changes in this methylation can have large-scale effects on bacterial gene regulation (Fang et al. 2012) and modulate bacterial phenotypes including virulence (Low et al. 2001; Heusipp et al. 2007).
Our findings call for better consideration of the large-scale effects of landscape on plants both in scientific studies and management plans.
However, the long-term and large-scale effects of browsing on forest succession are not possible to project without the use of simulation models.
