Analysis of the age distribution of gene duplications supported a continuous mode of small-scale duplications, plus two episodes of large-scale duplicates of vastly different ages.
This may indicate that genes associated with structural, RNA and lipid binding proteins were either more apt to be duplicated, or that these genes once duplicated as a result of the two rounds of large scale duplication observed by Schlueter et al [ 6], were retained whereas the duplicated genes in other classifications were lost or diverged significantly in primary sequence.
The human clusters are positioned on chromosomes (chr 1, chr 12) that have been reported to contain a number of genes duplicated during large scale duplication events [ 7].
Evolutionary distance analyses of these duplicated genes indicated two rounds of large scale duplication events had occurred in G. lamblia genome.
Duplicated genes, resulting from large scale duplications, initially possess the same regulatory elements and identical amino-acid sequence and are therefore thought to be redundant in their function, which means that inactivation of one of the two duplicates should have little or no effect on the phenotype, provided that there are no dosage compensation effects [ 17].
The relative age of grape duplicated genes was estimated and this made possible to reveal a relatively recent Vitis-specific large scale duplication event concerning at least 10 chromosomes (duplication not reported before).
We propose that the identified segmentally duplicated gene pairs were mostly conserved after the large-scale duplication event of each species during its evolution.
To better understand how WRKY III genes evolved, i.e., whether they arose from a large-scale duplication event (duplicated blocks derived from whole-genome or segmental duplication) or tandem duplication, we examined the physical locations of all WRKY III genes.
The implementation of such models in a full phylogenetic framework is expected to enable large scale probabilistic analysis of duplicates in comparative genomic studies.
To distinguish those LSG non-LSG pairs which have originated from LSG non-LSG segmentally dupairsted blocks, paralogous syntelogs in Arabidopsis thaliana whichidentified using SynMap (powered by DAGchaveer [ 34]) part originatede package [ 35].
Here we report a large scale analysis of asymmetric evolution of gene duplicates in five teleost fish genomes [ 7].
