In light of this, our data is most easily conceived in the absence of large-scale dosage compensation in chicken.
In the absence of large-scale dosage compensation, expression of Z-linked genes might be expected to be twice as high in males as in females.
Strain-matched comparison to the Sanger NGS data is somewhat limited, as the data include many call types that cannot be assessed with microarray analysis (as several classes of structural variation do not result in a large-scale dosage change).
If we assume that the absence of large-scale dosage compensation in chicken is representative for other birds this obviously raises the question of how birds can cope with an imbalance in the expression levels of sex-linked genes in males and females.
Two proteins identified by the screen are shown to be proteolytic substrates of Dsk2, validating the large scale synthetic dosage lethality screen as a new strategy for identifying substrates of a specific degradation pathway.
Before or during the development of solid dosage forms, large scale development trials are normally preceded by the evaluation of possible interactions between a drug and different excipients used in the formulation process.
The dosage form must also be suitable for manufacture on a large scale with reproducible quality.
"Alyse Rosner: Large Scale Work".
He does this on a large scale.
Large Scale Biology Corporation.
See also: Large scale Internet telephony.
