Although Rutkowski and Svetina (2014) proposed more liberal cutoff values to evaluate change in model fit for large-scale data analyses, these differences are mainly justified with the larger number of groups (i.e., countries).
However, the large-scale data analyses associated with RNA-seq harbors challenges.
Fortunately, in recent years, cloud computing has emerged as a viable option to quickly and easily acquire the computational resources for large-scale data analyses [ 7- 9].
Obviously, changes in this parameter lead to detection of different clusters, demonstrating the high dependence of large-scale data analyses on parameter selection.
In this article we primarily utilize our own database, YeTFaSCo, in which we integrated all other motif sets available as of its publication in 2011 (from the literature, large-scale data analyses, and computational analyses).
Currently, there are only two PaaS platforms in bioinformatics belonging to web servers, namely, Eoulsan [ 27], which is a cloud-based platform for high-throughput sequencing analyses, and Galaxy Cloud [ 28, 29], which is a cloud-scale Galaxy for large-scale data analyses.
Efficient parallel/concurrent algorithms and implementation techniques are the key to meeting the scalability and performance requirements entailed in such large scale data mining analyses.
Large scale data sharing No. Yes.
A hallmark of modern biology is tremendous amounts of complex omics data, which require large-scale data management, comprehensive computational analyses, fast retrieval and efficient integration for better understanding of the data and more effective hypothesis generation.
Just at the moment of finishing our paper, the results from another laboratory using cell-based RNAi assays and large-scale RNAi data analyses provided additional support to our conclusion, demonstrating that there is no definite correlation between siRNA stability and gene silencing in mammalian cells [30].
In essence, Rainbow is a wrapper of Crossbow, which can handle additional challenges in large-scale WGS data analyses.
