If biomedical research community can collaborate in organizing large-scale consortium of clinical trials associated with well-designed biobanks, these studies would soon act as huge laboratories for investigating genomic medicine; a big step forward towards personalizing medicine.
94 Large-scale, consortium-wide pregnancy RCTs as well as smaller regional RCTs have been implemented in the past several years to investigate the impact of lifestyle interventions during pregnancy and early life.
The potential to rapidly identify predictive biomarkers of drug response in tumor tissue to define sensitive and resistant patient cohorts has recently been accelerated through advances in functional genomics techniques that have been intensively developed by the PREDICT consortium using large scale RNAi screening approaches [ 44- 47].
After nine years of building and running the HAMAP pipeline, the results of this large scale experiment warrant that the UniProt consortium embark in a similar project targeting eukaryotic organisms.
Cultivation efforts at large scale are intensive and costly, therefore the consortium developed tools and models to assess the productivity of strains under various environmental conditions, at lab scale, and validated these against scaled outdoor production systems.
The project, called the Structural Genomics Consortium, stands out for its large scale and tight focus.
Recent developments in genetics such as the Human Genome Project [43], the Single Nucleotide Polymorphism (SNP) Consortium [44] and the International HapMap project [45], [46], coupled with technological advances, have allowed large scale genotyping to be undertaken as exemplified by the Wellcome Trust Case Control Consortium [47].
We demonstrate the new LONI Pipeline features using large scale neuroimaging studies based on data from the International Consortium for Brain Mapping [5] and the Alzheimer's Disease Neuroimaging Initiative [6].
In the case I wrote about, the war room announced a new business consortium that will attempt building retrofits on a large scale in the United States, starting in Miami and Sacramento.
Recently, a large scale map of 6200 PPIs was completed for Arabidopsis (Arabidopsis interactome mapping consortium, 2011).
In 2013, we initiated the UNIVRSE (Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement)—consortium in order to investigate causes and consequences of VRS on a large scale [ 74].
