Sentence examples for large scale conformational changes from inspiring English sources
In addition to signature phenomena in supercooled liquids, we apply this microscopic picture to the phenomenon of slaving of large scale conformational changes of a folded protein, imbedded in a glass-forming solvent, to the solvent motions.
Our results reveal that the CNB domains persist as relatively denaturation-resistant cores, a feature that might be advantageous for permitting large scale conformational changes that are of importance for the different functional states of RIα.
However, the causes for the induction of apoptotic pathway are unclear, as the H35N can neither undergo large scale conformational changes nor it is efficient in inducing membrane damage.
Thus, the MD simulations suggest that large scale conformational changes, to fully dissociated NBDs observed in the crystal structures, are not required to release ADP or drug.
Such a forced tilting of the α-helix in the middle of a TM segment, which is accompanied by large scale conformational changes [ 21, 31, 59, 61, 62, 64, 65, 67, 68], is an unusual feature that probably could have emerged just once, being shaped by the light-driven isomerization of the retinal.
Thus, it is reasonable to deduce that this single point mutation would not induce a large scale conformational change at the MIDAS site and related interface with PA.
We also show that relatively small structural transitions occur at the nucleotide-binding site on Mg-ATP binding, but that these lead to larger scale conformational changes and neck linker docking.
While the resolutions achievable are still lower than what is required to understand enzyme catalysis at as detailed a level as available for DHFR or CypA, a fairly thorough picture of larger scale conformational changes can be developed through comparison of density maps and de novo models.
This makes transition networks powerful tools for understanding large-scale conformational changes.
Therefore, large-scale conformational changes are necessary to bring Thr379 close to the substrate.
Macromolecular machines, such as the ribosome, undergo large-scale conformational changes during their functional cycles.
