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There are many logistic problems to organizing such a large scale comparative study, and a secondary comparison with data harmonization is the most feasible option in addressing our research question.
Large scale comparative study employing qualitative data collection techniques: semi-structured interviews with key informants, task-groups, and workshops; framework analysis of qualitative data informed by Normalization Process Theory.
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Large scale comparative studies on TRs of the human genome are described in Ames et al. (2008) and Warburton et al. (2008).
FiloDetect provides accurate and objective quantification of filopodia in microscopy images, and will enable large scale comparative studies to assess the effects of different genetic and chemical perturbations on filopodia production in different cell types, including cancer cell lines.
The same conclusion was reached by several large scale comparative studies, based on transcriptomic or proteomic analyses, which lead to the identification of biological processes and genetic determinants affecting rice grain properties.
Given that extraction of chloroplast DNA from a wide range of rainforest tree species is time consuming and would require optimisation across a range of taxa, this method using whole genomic DNA, sequenced on the Illumina platform, is preferable for large scale comparative studies of plants.
Its portability makes possible potentially large-scale comparative study of developmental milestones in both neurotypical and autistic children.
In the first large-scale comparative study of secreted protein production using these viral vectors, we have evaluated production of 16 recombinant enzymes specifically, we exploited these viral vectors, termed 'BacMam' viruses, to drive expression of a panel of proteases selected from all four major mechanistic classes, including secreted, lysosomal, endosomal, and type I transmembrane proteins.
The first large-scale comparative study on the effects of treatment with the antimalarial drugs artemisinin and chloroquine on the proteome of P. falciparum was performed using metabolic labeling followed by identification and quantification with MudPIT LC-MS.
We performed a large-scale comparative study that included 87 squid species and 237 species of acanthomorph fish.
The present analysis offers the first large-scale comparative study of the proteomic architectures of all the archaeal species of publicly available genome sequences.
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