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Only large scale clinical testing will help us with understanding these molecular subtypes and designing therapies for patients with DLBCL.
The development of protein biomarkers in serum requires the availability of reliable analytical tools for the unbiased prioritization and large scale clinical testing of novel candidates [ 38, 39].
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Its diabetes treatment Onglyza, developed with Bristol-Myers Squibb, failed to reduce heart risks or strokes in a large scale clinical trial.
Many candidate vaccines targeting neglected diseases in low- and middle-income countries are now progressing to large-scale clinical testing.
However, point-mutation assays are susceptible to polymorphisms and their performance with large-scale clinical testing is unclear.
However, a large-scale clinical testing is warranted to further validate this assay.
Ongoing, large-scale clinical testing will provide additional insights into the potential role of relaxin in the treatment of heart failure.
But knowing it was behind Novartis, Merck gambled and moved immediately into large-scale clinical tests on more than 1,000 patients.
Hence, a large-scale clinical test including the early stage samples will be necessary.
Indeed, there was a large-scale clinical trial to test its beneficial effects in stroke patients.
Because it seems unlikely that a large-scale clinical trial to test the impact of existing hypoglycemic pharmacotherapies on CVD will be performed, data from observational studies may provide important information to guide clinical practice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com