However, to achieve the status of routine large-scale clinical practice, automation and scale-out processes are required.
Such a strategy could also be encouraged to design future interventional studies with the newer classes of compounds (angiotensin II AT1-receptor antagonists, vasopeptidase inhibitors, endothelin antagonists), which would have the additional potential advantage of providing information more easily transferable to large-scale clinical practice.
Despite the fact that gene expression data from lung tissues should provide greater sensitivity to detect the molecular signature of COPD exacerbations, COPD is a systemic disease, and blood is more accessible for genomics and biomarkers studies in large scale clinical trials and potentially in clinical practice than is lung tissue samples.
We next evaluated the ability of our STS predictor to reclassify formalin fixed paraffin embedded NOS samples in order to assess its broader applicability for clinical practice and future large scale clinical research.
Well designed, large scale clinical trials are currently the mainstay of influencing changes in clinical practice.
Its diabetes treatment Onglyza, developed with Bristol-Myers Squibb, failed to reduce heart risks or strokes in a large scale clinical trial.
However, further studies are necessary to evaluate whether these tools provide any additional prognostic value when used in combination with clinical risk scores (Table 2) before they can be implemented on large scale in clinical practice.
If the trial proves a successful outcome, the TES program can be made available for implementation on a larger scale in clinical practice.
The most accurate (within 10% of the gravimetric gold standard) and most reproducible (< 5% between-test variation) are also, unfortunately, the most expensive and most difficult to implement for purposes of large-scale clinical trials or for routine clinical practice.
The novel AR and IRAR indexes are cost-effective, precise, reproducible and reliable integrated diagnostic biomarkers of insulin sensitivity for screening subjects with increased risk of future development of T2DM and MS. These surrogate indexes are useful for early diagnosis of insulin resistance, T2DM and MS in the daily clinical practice and for large-scale clinical investigation.
