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Some of the precipitation changes are associated with large scale changes to atmospheric wind patterns that are moving climate zones.
It aims to shed light on health problems induced by large-scale changes to the environment, and to highlight new ways of working to address these often intractable issues.
When the menace of unemployment is a widespread concern, the possible benefits of large-scale changes to the health-care system may well be outweighed, for many, by the fear of economic fallout from such a vast and expensive new program.
Agricultural intensification in Northern Ireland has brought about large-scale changes to the landscape with a detrimental effect on biodiversity.
A decline in bumblebee numbers could cause large-scale changes to the countryside, resulting from inadequate pollination of certain plants.
Just last month President Obama, while arguing Americans "instinctually understand" the need for reform, admitted imposing such large-scale changes to the tax system will be like "pulling teeth".
Large-scale changes to the environment, including geological and climatic events, can affect the evolutionary history of entire communities of co-distributed species and their associated microbiota.
Mr. Vacca said he was surprised that the city would engage in a large-scale change to the city's roads without a more precise count of how many New Yorkers might use it.
In general, circadian regulation of the enzymes mediating C4 photosynthesis was predictable based on the Arabidopsis C3 model and without any apparent large-scale changes to accommodate the specialized C4 anatomy and enzymology.
Small changes to a 'master switch' can lead to large-scale changes to gene expression resulting in the same tissue on the same organism becoming functionally distinct.
Sudden and large-scale changes to fishes' water can adversely affect the chemistry of the tank and potentially put your fish into shock.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com