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Several expression profile studies in Arabidopsis have established that large scale changes occur in gene expression during cold acclimation and subsequent freezing tolerance [ 25- 27].
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When large-scale changes occur, the genomic size and gene content of the diverging genomes may remain similar, but the physical locations and/or orientations of certain chromosomal segments can differ among the diverging lineages.
The answer to this question lies with the large scale changes that occur in tobacco leaf chemistry as the tobacco cures.
Our studies reveal that large scale changes in gene expression occur in ookinetes between 16 and 24 hours after fertilization, possibly required for the differentiation of (retort-form) zygotes into the mature ookinetes.
Our results using ChIP assays provide the first evidence of large scale changes in c-Myb DNA binding activity occurring in response to cellular signals, and provide a new platform for studies of c-Myb regulation in future studies.
Some large scale changes like gene duplications and genomic rearrangements have, however, occurred within the galliform lineage.
There were no large scale changes observed in the karyotype.
These large scale environmental changes occurred during periods of intensive ancient Maya land use and climatic instability, both of which may have contributed to erosion by increasing runoff.
Some large-scale changes could occur abruptly, i.e., over a short time period, and might also be irreversible.
In Figs. 3A and B one can compare the levels of LDH and XTT in the control and in cells treated with 90 μM MP-MUS to be alerted to the fact that large-scale metabolic changes occur in response to MP-MUS.
We need business to weigh in on policy if we are to reach large scale change.
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