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The spatial organization of the genome plays an important role in the regulation of nuclear functions and undergoes large scale changes during differentiation.
One other similarity to our study was the identification by Poole et al. [ 14] of antisense transcripts related to transcription, such as nucleotide binding proteins, which the authors suggest may enable the control of multiple pathways that require large scale changes during development.
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As enhancer usage is largely cell-type-specific, it is not surprising that these interactions are also unique to different cell types and undergo large-scale changes during differentiation [ 63].
As genomes may undergo large-scale changes during evolution, global alignments using the Mauve alignment tool [ 17] were performed by pairwise comparison of the seven C. concisus strains with the reference BAA-1457 strain.
Several expression profile studies in Arabidopsis have established that large scale changes occur in gene expression during cold acclimation and subsequent freezing tolerance [ 25- 27].
Likewise, chromatin remodelling was suggested by Druart [ 24] to explain the large scale changes in transcription observed in poplar cambial meristems during seasonal dormancy transitions.
It's more associated, therefore, with large scale changes.
"Weather is chaotic, which means that even a microscopic disturbance can lead to large scale changes.
These studies indicate that large scale changes in xyloglucan crosslinking in cell wall mediated by XTHs may facilitate movement and separation during flower opening and abscission respectively.
There were no large scale changes observed in the karyotype.
We need business to weigh in on policy if we are to reach large scale change.
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