This comparative analysis identified cell cycle networks preferentially involved in mitotic progression as well as large scale changes in the expression of histones and non-protein coding RNAs as the major distinctions between the hyperthermic responses between the breast cancer lines and the MCF10A cells.
The answer to this question lies with the large scale changes that occur in tobacco leaf chemistry as the tobacco cures.
There were no large scale changes observed in the karyotype.
Large scale climatic changes, as have been experienced in the past, are expected to have an effect on the timing of migration.
The lidar, hyperspectral, and multispectral sensors, and the methods demonstrated here can be widely applied across a gradient of vegetation and topography for monitoring landscapes undergoing large-scale changes such as the forests in the southwestern U.S.A.
The large numbers of pseudo mt genes we found in L. entomophila and L. paeta in this study and in L. bostrychophila [ 13] are extraordinary for insects and animals, indicating that large-scale changes, such as tandem duplication or mt chromosome duplication, occurred relatively recently in the multipartite mt genomes of these booklice.
Indeed, the genomes of drug-resistant strains isolated following clinical treatment often exhibit large-scale changes, such as loss of heterozygosity (LOH) (Coste et al., 2006; Dunkel and Morschhauser, 2011), copy-number variation (CNV), including short segmental CNV, and whole chromosome aneuploidy (Selmecki et al., 2010) accompanied by point mutations.
The expansion phase of the magnetospheric sub-storm explosively releases the stored energy causing large-scale changes in the magnetosphere as well as in the ionosphere: particle acceleration and precipitation, fast plasma flows, enhanced field-aligned currents, enhanced ionospheric electrojets, and spectacular auroral displays.
Both large-scale shape changes as well as local features associated with necking can be captured.
