To gain a large-scale cellular and molecular perspective on the biology of coral-dinoflagellate symbiosis, we have developed a suite of cDNA libraries that encompass significant stages in coral life history and symbiotic stages, including unfertilized eggs, two stages of embryonic development, cohorts of larvae that are either symbiotic or non-symbiotic, and adult coral.
One disadvantage of measures that are based on a set of reference genes is the fact that in the case of organisms with poor genomic data and without large scale cellular measurements, creating a meaningful reference set is challenging.
But, bacteria just don't seem to have the GTPases that we associate with eukaryotic signaling and large-scale cellular organization, and (particularly in animals) with complicated kinds of multicellular life.
Kell, D. B. Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.
Spermiogenesis offers a good model for investigating the molecular basis of large-scale cellular morphogenesis and movement.
SNAVI is a software tool for statistical analysis and visualization of large-scale cellular signaling networks and other biochemical intracellular networks.
This works fine for the purpose at hand, but forgoes the opportunity for flexibility and truly large-scale cellular organization that are intrinsic features of both the eukaryotic actin and microtubule cytoskeletons.
However, a major drawback in the application of chromosome-based DNA is the lack of a suitable and convenient procedure for large-scale cellular introduction, which is particularly frustrated by their size (1 by 2 μm).
Effective analysis and visualization tools for large-scale cellular networks that can draw connectivity diagrams with an unbiased predisposition from large interaction datasets can help cell and molecular biologists identify potential new pathways and sometimes predict missing components and interactions.
In turn, these biological switches regulate large-scale cellular processes, e.g., commitment to cell division, cell differentiation, and phenotypic alterations.
Koleti, A. et al. Data Portal for the Library of Integrated Network-based CeLINCSr Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data.
