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While expression analysis in the nervous system is today largely based on large scale approaches like microarray and Serial Analysis of Gene Expression [19], the functional analysis of this expression data represents a major bottleneck.
"We believe that large scale approaches continue to provide exciting opportunities," said NHGRI Deputy Director Mark Guyer.
Shifting from Macro to Micro, I traded large scale approaches for face-to face problem solving.
There are also large scale approaches, capable of validating many antibodies simultaneously (Holm et al., 2012).
With thousands of microbial genomes waiting to be deciphered, large scale approaches are needed.
Many host genes and proteins responding to WSSV infection were also identified through large scale approaches [ 3– 7].
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"This is a relatively small release, however it is the beginning of a large scale approach to prevent the extinction of this species.
The opportunity to study these proteins quantitatively and differentially in a large scale approach will support future drug development strategies.
Here we present a large scale approach that aimed at identifying nodule-associated genes, and more specifically putative regulators of gene expression.
Our large scale approach confirmed the importance of genomic biases but also unveiled important translational biases that shape codon-pair context and should be primary targets for mistranslation hot spots.
Here, we analysed in a large scale approach whether this flexibility in evolution is only limited to a distinct number of complexes or represents a more general trend.
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