Sentence examples for large scale alterations in from inspiring English sources

Ten samples show large scale alterations in the CN of chromosome 6, including 6 samples with a baseline CN of 3, and one more with a baseline CN of 4. Six of the chromosomes show large regions of relative LR loss in the q-arm, with the common region spanning 159 Mbp to the q-term (170 Mbp).

Besides being responsible for abrupt large-scale alterations in the structure and organization of X. fastidiosa genomes, the prophages are also capable of carrying some "cargo" genes with function not directly related to the phage propagation.

These changes may be further followed by large-scale alterations in genomic DNA [ 19].

Our transcriptomic data reveal large-scale alterations in the expression of genes involved in chitin metabolism and puparial adhesion.

These data suggest that mild hyperthermia induces large-scale alterations in gene expression profiles across normal and breast cancer cell lines.

Plant growth and crop productivity is largely limited by environmental factors that include water-deficit stress, such as by salinity, which bring about large-scale alterations in gene expression in plants [ 7]. High NaCl concentrations in soil cause salinity stress and limit the geographical distribution of most highly salinity-sensitive plants, including legumes [ 8, 9].

In addition, we demonstrated that the abundance of the vast majority of histone species do not significantly change in primary tumor samples and cell model systems suggesting that at least some malignancies are not accompanied by large-scale alterations in the global histone proteome.

Transcriptome studies have shown that large scale alterations of transcript abundances is a common feature of Fe deficiency and thus plays a key role in the Fe deficiency response [ 15- 17].

This suggests an extensive and large scale alteration of the metabolic system in the SPF small intestine.

Only in 5WexGF intestines, both SI and LI, large scale alteration of chemokine signaling was observed.

In all 3 groups, the profiles of SI were characterized by large scale alteration of EGF, platelet-derived growth factor (PDGF) and NGF/neurotrophin signaling.