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One category, which is operated on a relatively large scale, aims to purify the membrane protein complex from membrane fractions while retaining its native form, mainly to characterize its nature.
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Although this insertional screening was carried out on a large scale aimed at identifying genes essential for early development, the phenotypic descriptions of these insertional mutants were rather preliminary and most of the images provided were taken at 2 to 4 dpf.
Once this technology appeared as a promising alternative conversion pathway of a residual feedstock such as WCO into biodiesel, it was further explored in a larger scale, aiming to demonstrate its effectiveness.
In the last years, the progress on low temperature detector technologies has allowed to design large scale experiments aiming at pushing down the sensitivity on the neutrino mass below 1 eV.
In conclusion, this work represents the first large scale study aiming at evaluating the implication of miRNAs during asthma, from early inflammation to chronically remodelled airways.
For large scale studies aiming at a better understanding of mitochondrial DNA (mtDNA), sequence variation in particular mt haplogroups (hgs) and population structure, reliable low-cost high-throughput genotyping assays are needed.
Given the announcement of a $4 million investment in the National Hand Hygiene Initiative in May 2009, it may be that there will not be the funds to support another large scale initiative aimed at, what may be perceived to be, a very similar healthcare objective.
Such information is necessary for the development of large scale studies aiming to map eQTL that are relevant to our understanding of brain and behavioral traits.
The primary problem the large scale SEHR aimed to address was the availability of information for a highly mobile and remote population.
Large scale projects aimed at sequencing the complete genomes of many crop and model plant species have been preceded by smaller scale efforts that informatively sample and annotate limited but representative genomic regions.
It can also be used in large scale surveys aimed at identifying depraved populations in order to identify groups which may benefit from interventions, as has been done previously [ 34].
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