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In contrast to immunization with transfected DC, immunization with the naked DNA plasmid encoding LAMP/gag results in transfection at the site of immunization of large numbers of muscle and other non-professional MHC class I APCs and likely results in relatively large scale activation of CD8+ T cells [30].
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The timing of large-scale activation of the embryonic genome is species-specific.
Preparation of transcriptional machinery to the large-scale activation of gene expression appears a major developmental event that takes place during MBT.
Actively demyelinating WM lesions that continuously emerge and regress during disease are characterised by disruption of the blood-brain barrier, marked leukocyte infiltration, and large-scale activation of microglia/macrophages.
A large-scale activation of gene categories involved in the modulation of apoptosis (10 GO categories) and of oxidoreductase activity (4 GO categories) appears to be a common denominator of the two experimental paradigms.
This aim was achieved through a large-scale activation likelihood estimation (ALE) analysis of 386 studies (3952 activation peaks) covering 8 cognitive domains.
Using a detailed analysis of c-fos staining as a measure of neuronal activity in mice upon exploration of an enriched environment, our group found no difference between reeler and WT animals in c-fos expression levels, suggesting that the neuronal networks in these genotypes do not differ in terms of large-scale activation in response to a whisker-dependent behavior (Wagener et al. 2010).
This assumption was tested by conducting a large-scale activation likelihood estimation (ALE) meta-analysis of neuroimaging studies, which assessed 2,607 peak coordinates from 247 experiments in 1,790 participants.
But researchers like Bruce McEwen, a neuroendocrinologist at Rockefeller University, and Frances Champagne, a neuroscientist at Columbia University, have shown that repeated, full-scale activation of this stress system, especially in early childhood, can lead to deep physical changes.
Additionally, we found evidence of large scale simultaneous HFO activation, most often in association with macrodischarges, but with marked differences in the oscillation characteristics between channels; these were rarely seen in the only patient recorded outside the epileptogenic zone.
Newspapers are on the large scale side of print advertisement.
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