Sentence examples for large scale abnormalities from inspiring English sources

Schizophrenia has also been described as a syndrome involving large scale abnormalities of synaptic efficacy, especially within systems responsible for emotional learning and memory (Friston 1998).

If a large-scale abnormality in translational repression prevented meiotic maturation, one might imagine that such a block might be recapitulated by other mutations that perturb gene expression in oocytes or other insults to oocyte physiology.

In 8013 tumour samples spanning 29 tissue types, we did not find a single translocation, homozygous loss, insertion/deletion, or any other inactivating large-scale chromosomal abnormalities.

Large scale clinical studies have demonstrated that cytogenetic abnormalities provide valuable information of prognostic relevance.

Chromosomal abnormalities, that is to say large scale alterations to the DNA, be they deletions, duplications or translocations, can have more severe effects.

B. marinus are widely distributed and therefore can be studied at very large scale to provide important information about the distribution of abnormalities associated with various forms of land use including a diversity of agricultural uses.

In the interest of parsimony, the central theme of our framework is that the symptoms of schizophrenia can be accounted for without necessarily evoking abnormalities in a central control mechanism or in large scale coordination of brain systems.

IC1 and IC2 methylation profiling can also detect copy number abnormalities – most of which are IGF2/H19 duplications and large scale CDKN1C/IC2 deletions – though each of these findings is rare [ 10].

Accumulating data from several large scale trials of patients with T2DM also point to early lipid abnormality as a major independent risk factor for the development of diabetic nephropathy [ 10], but the early effects of triglyceride and cholesterol abnormalities on renal injure in T1DM are not fully understood and the mechanisms underlying this need further exploration.

Additionally to sequential event models, large scale analysis of genomes from patient's tumors have shown that multiple genetic abnormalities can promote the development of one cancer entity [ 4].

Large scale expression analyses of mature miRNAs revealed specific miRNA patterns that were associated with recurrent genetic abnormalities in AML [ 10- 124]24].