Exact(26)
Therefore, when the discovery samples have insufficient power, SNPs selected for replication based on small P-values may not replicate (even in sufficiently large replication samples) because they are false positives.
In the psychology department at the University of California, Santa Cruz, we recently carried out a large replication of a classic study showing that print has a richer vocabulary than speech.
We propose a large replication study to provide a less biased effect size estimate.
From a number of recent structural studies it is clear that during the viral life cycle large replication complexes are formed, which involve a large number of viral proteins [31].
In brief, all three publications used a discovery dataset where GWA evaluation was performed on Illumina or Affymetrix chips and promising genetic variants were further tested for replication in large replication datasets.
Overall, the possible weak association in a single Dutch sub-population and the negative association in three large replication cohorts, imply that the ERCC6 C-6530>G polymorphism has a minor role, if any, in the pathogenesis of AMD.
Similar(34)
In a replication analysis by genomic qPCR, the prognostic implication of ERBB2 gain (RAR-G13) was successfully replicated in the larger replication set, but that of the NUPR1 gain (RAR-G12) was not.
To examine the robustness of the MD statistic to changes in replication, we considered a comparison between two mouse datasets with larger replication, the ESCs dataset of (Booth et al., 2014) with four replicates and the neural dataset of Varela-Rey et al.
A larger replication study is currently underway to try to confirm this finding.
The largest replication effort so far, published online this week in Psychological Medicine, identifies the same region, known as Xq28.
These findings suggest that ongoing inflammatory responses may be linked to disturbances in behavior and require confirmation in larger replication studies.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com