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Instead the loss of USP14 led to a large reduction in the number of presynaptic vesicles.
A number of control measures have been implemented for classical scrapie, and since 2005 there has been a large reduction in the number of observed cases.
When the full autocorrelation structure and long-term persistence behavior were taken into account in the trend analysis, there was a large reduction in the number of rivers with significant changes in streamflow.
Together such changes have led to a remarkable increase in output of major agricultural products, but they have also resulted in a large reduction in the number of agricultural workers and the increased indebtedness of many farmers, and the related negative effects on the environment have given rise to the organic farming movement.
This typically allows for a large reduction in the number of paths to be inspected.
However, a recent report from market research firm NPD suggested that there had been a large reduction in the number of users illegally downloading music, with fans instead favouring legal options like streaming site Spotify.
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The largest reduction in the number of accidents is found for residential streets (about 25%), a somewhat smaller reduction is found for main roads (about 10%).
This is the reason why there is not-so-large reduction in the number of operations on these instances with respect to others.
For example, biofumigation using Lavandula plant materials can result in large reductions in the numbers of viable microsclerotia recovered.
It has risen but only by a small amount - looking at the longer term trends shows this is mostly attributable to a large scale reduction in the number of Finns in Sweden!
In contrast, we observed a large and significant reduction in the number of GLR-1 GFP GLR-1 GFPmagi-1(tm446) mutants that had been expunctato prinr magi-1 tm446 magi-1 tm446
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