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The review and analysis of a large range of test cycles enabled first the building-up of a set of contrasted cycles specifically designed for characterizing the influence of the driving conditions.
Some of these approaches have shown adequate accuracy when applied to small sets of beam tests, while their ability to predict the effect of a large range of test variables remains unknown.
A large range of test brands were used to estimate the sensitivity and specificity of microhaematuria, as shown in Appendix 7. Most evaluations (n = 25; 34%) were performed with the brand from the manufacturer Ames.
A large range of test brands were used to estimate the sensitivity and specificity of proteinuria, as shown in Appendix 9. Most evaluations (n = 17; 37%) were performed using the brand from the manufacturer Ames.
The concentrations used in this study were the highest non-cytotoxic concentrations (designated here as the benchmark concentration, BMC) experimentally determined by exposing cells to a large range of test concentrations and then recording their viability using a resazurin reduction assay.
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Despite the large range of tested melt compositions (0 < CaO and MgO < 40; 40 < SiO2 < 100; in wt%), we found that Na2O solubility is conveniently modeled as a linear function of the optical basicity calculated on a Na-free basis melt composition.
The same trend, in which mixed-CLR coupled with Inferelator 1.0 outperforms the other evaluated method combinations for a large range of tested filtration cutoffs, holds for DREAM3 50-gene networks (for which our method ranked 4th out of 27) and 10-gene networks (for which our method ranked 5th out of 29) (data not shown).
Researchers have tried "a phenomenally large range" of diagnostic tests on available samples, says Klaus Stöhr, an influenza expert at WHO in Geneva, but they have all been negative.
Ultimately, the fact that the large range of temperatures tested did not contain the full thermal range of juvenile guppies is indicative of the fact that this species has adapted a wide thermal range that enables them to be effective thermal adaptors and may account for their success as an invasive species.
Nuclear imaging has the benefits of high intrinsic sensitivity, recognising targets present in a very low concentration, exceptional penetration of tissues, whole-body visualisation, and a large range of available, clinically tested tracers and consequently a high specificity [ 1, 2].
Fiona produces corrections of similar quality with difference in gain value <15%, despite the large range of error rates tested, which indicates robust automatic parameter selection (see Supplementary Table S3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com